Gabamide

Gabamide, or GABAmide, also known as γ-aminobutyramide (GABAD), is a GABA receptor agonist and GABA analogue, or more specifically the amide of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).^[1][2] Along with GABA and progabide acid (SL-75.102), gabamide is an active metabolite of the anticonvulsant drug progabide (Gabrene; SL-76.002).^[1][2] Unlike progabide, but similarly to GABA, gabamide is unable to cross the blood–brain barrier and hence is peripherally selective.^[2] However, gabamide and GABA are formed in the brain from progabide following its entry into this part of the body.^[2]

Other namesGABAmide; GABAMIDE; GABA amide; 4-Aminobutanamide; 4-ABAD; 4-Aminobutyramide; gamma-Aminobutyramide; γ-Aminobutyramide; GABAD; gamma-Aminobutyric acid amide; γ-Aminobutyric acid amide

Drug classGABA receptor agonist

ATC code

• None

CAS Number

• 3251-08-9

Quick facts Clinical data, Other names ...

Gabamide

Clinical data
Other names	GABAmide; GABAMIDE; GABA amide; 4-Aminobutanamide; 4-ABAD; 4-Aminobutyramide; gamma-Aminobutyramide; γ-Aminobutyramide; GABAD; gamma-Aminobutyric acid amide; γ-Aminobutyric acid amide
Drug class	GABA receptor agonist
ATC code	None
Identifiers
IUPAC name 4-aminobutanamide
CAS Number	3251-08-9
PubChem CID	18615
ChemSpider	17581
UNII	DQN3YXP96S
ChEMBL	ChEMBL1199935
CompTox Dashboard (EPA)	DTXSID80186235
ECHA InfoCard	100.019.852
Chemical and physical data
Formula	C4H10N2O
Molar mass	102.137 g·mol−1
3D model (JSmol)	Interactive image
SMILES C(CC(=O)N)CN
InChI InChI=1S/C4H10N2O/c5-3-1-2-4(6)7/h1-3,5H2,(H2,6,7) Key:WCVPFJVXEXJFLB-UHFFFAOYSA-N

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