CLC (gene)

Galectin-10 is an enzyme that in humans is encoded by the CLC gene.^[3][4]

PDBHuman UniProt search: PDBe RCSB

AliasesCLC, GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN, Charcot-Leyden crystal galectin, galectin-10

External IDsOMIM: 153310; HomoloGene: 130498; GeneCards: CLC; OMA:CLC - orthologs

Chr.Chromosome 19 (human)^[1]

Quick facts Available structures, PDB ...

CLC
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1G86, 1HDK, 1LCL, 1QKQ
Identifiers
Aliases	CLC, GAL10, Gal-10, LGALS10, LGALS10A, LPPL_HUMAN, Charcot-Leyden crystal galectin, galectin-10
External IDs	OMIM: 153310; HomoloGene: 130498; GeneCards: CLC; OMA:CLC - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 39,731,255 bp[1] End 39,738,029 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone bone marrow bone marrow cell testicle monocyte blood gallbladder appendix granulocyte mucosa of transverse colon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type endopeptidase activity involved in apoptotic process lysophospholipase activity protein binding carbohydrate binding identical protein binding Cellular component cytoplasm cytosol collagen-containing extracellular matrix Biological process multicellular organism development T cell apoptotic process regulation of T cell cytokine production regulation of activated T cell proliferation regulation of T cell anergy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1178 n/a Ensembl ENSG00000105205 n/a UniProt Q05315 n/a RefSeq (mRNA) NM_001828 n/a RefSeq (protein) NP_001819 n/a Location (UCSC) Chr 19: 39.73 – 39.74 Mb n/a PubMed search [2] n/a
Wikidata
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Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias.^[4]