Galectin-2

Galectin-2 is a protein that in humans is encoded by the LGALS2 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesLGALS2, HL14, galectin 2

External IDsOMIM: 150571; MGI: 895068; HomoloGene: 4741; GeneCards: LGALS2; OMA:LGALS2 - orthologs

Chr.Chromosome 22 (human)^[1]

Quick facts LGALS2, Available structures ...

LGALS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HLC
Identifiers
Aliases	LGALS2, HL14, galectin 2
External IDs	OMIM: 150571; MGI: 895068; HomoloGene: 4741; GeneCards: LGALS2; OMA:LGALS2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,570,248 bp[1] End 37,582,616 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 78,735,060 bp[2] End 78,739,729 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder monocyte pancreatic ductal cell rectum granulocyte mucosa of transverse colon human kidney body of pancreas mucosa of ileum mucosa of sigmoid colon Top expressed in gastric mucosa epithelium of stomach mucous cell of stomach crypt of lieberkuhn of small intestine pyloric antrum duodenum migratory enteric neural crest cell ileum intestinal epithelium epithelium of small intestine More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 3957 107753 Ensembl ENSG00000100079 ENSMUSG00000043501 UniProt P05162 Q9CQW5 RefSeq (mRNA) NM_006498 NM_025622 RefSeq (protein) NP_006489 NP_079898 Location (UCSC) Chr 22: 37.57 – 37.58 Mb Chr 15: 78.74 – 78.74 Mb PubMed search [3] [4]
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The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to Lymphotoxin alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.^[7]