Gallopamil
Calcium channel blocker drug
From Wikipedia, the free encyclopedia
Gallopamil (INN) is an L-type calcium channel blocker that is an analog of verapamil. It is used in the treatment of abnormal heart rhythms.[1]
Other namesMethoxyverapamil
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| Other names | Methoxyverapamil |
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| Formula | C28H40N2O5 |
| Molar mass | 484.637 g·mol−1 |
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| Chirality | Racemic mixture |
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Synthesis
The alkylation reaction of 3,4,5-trimethoxyphenylacetonitrile (1) and isopropyl chloride (2), using sodium amide as base gives the intermediate nitrile (3). A second alkylation with a specific alkyl chloride (4) yields gallopamil.[2][3][4]
