Gamithromycin

Medication From Wikipedia, the free encyclopedia

Gamithromycin, sold under the brand name Zactran, is a veterinary medication used for the treatment of cattle, pigs, and sheep.[4][5][6] It is a azalide antibacterial related to azithromycin.[4][5][7]

Other namesML-1709460, ML-460
License data
Quick facts Clinical data, Trade names ...
Gamithromycin
Clinical data
Trade namesZactran
Other namesML-1709460, ML-460
License data
Routes of
administration
Subcutaneous
Drug classMacrolide antibiotic
ATCvet code
Legal status
Legal status
Identifiers
  • (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.123.704 Edit this at Wikidata
Chemical and physical data
FormulaC40H76N2O12
Molar mass777.050 g·mol−1
3D model (JSmol)
  • [H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)N(CCC)C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C
  • InChI=1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25-,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1
  • Key:VWAMTBXLZPEDQO-UZSBJOJWSA-N
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It was approved for veterinary use in the European Union in 2008.[4][5]

Veterinary uses

In the EU, gamithromycin is indicated for the treatment and prevention of bovine respiratory disease in cattle, swine respiratory disease in pigs, and infectious pododermatitis (foot rot) in sheep.[4][5][7]

In the US, gamithromycin is indicated for the treatment of bovine respiratory disease in cattle.[1]

References

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