Glypromate

Glypromate (Gly-Pro-Glu, GPE) is a tripeptide fragment derived from the N-terminus of the endogenous growth factor IGF-1. It has antiinflammatory and neuroprotective effects and is of interest in the treatment of neurological conditions such as Alzheimer's disease and Parkinson's disease. The simple GPE peptide has poor blood-brain barrier penetration and is rapidly metabolised in the body, however a number of synthetic derivatives of GPE have been developed with improved properties.^{[1][2][3][4][5][6][7][8][9][10]}

CAS Number

• 32302-76-4

PubChem CID

• 3080768

DrugBank

• DB05633

ChemSpider

• 2338502

Quick facts Identifiers, CAS Number ...

Glypromate

Identifiers
IUPAC name (2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]pentanedioic acid
CAS Number	32302-76-4
PubChem CID	3080768
DrugBank	DB05633
ChemSpider	2338502
UNII	ZYK4RVV5LS
ChEBI	CHEBI:163960
ChEMBL	ChEMBL371315
CompTox Dashboard (EPA)	DTXSID80186038
Chemical and physical data
Formula	C12H19N3O6
Molar mass	301.299 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1C[C@H](N(C1)C(=O)CN)C(=O)N[C@@H](CCC(=O)O)C(=O)O
InChI InChI=1S/C12H19N3O6/c13-6-9(16)15-5-1-2-8(15)11(19)14-7(12(20)21)3-4-10(17)18/h7-8H,1-6,13H2,(H,14,19)(H,17,18)(H,20,21)/t7-,8-/m0/s1 Key:JJGBXTYGTKWGAT-YUMQZZPRSA-N

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