HIST1H1E

Histone H1.4 is a protein that in humans is encoded by the HIST1H1E gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesH1-4, histone cluster 1, H1e, H1.4, H1E, H1F4, H1s-4, dJ221C16.5, histone cluster 1 H1 family member e, RMNS, HIST1H1E, H1.4 linker histone, cluster member

External IDsOMIM: 142220; MGI: 1931527; HomoloGene: 130534; GeneCards: H1-4; OMA:H1-4 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts H1-4, Available structures ...

H1-4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3TZD, 5JJZ
Identifiers
Aliases	H1-4, histone cluster 1, H1e, H1.4, H1E, H1F4, H1s-4, dJ221C16.5, histone cluster 1 H1 family member e, RMNS, HIST1H1E, H1.4 linker histone, cluster member
External IDs	OMIM: 142220; MGI: 1931527; HomoloGene: 130534; GeneCards: H1-4; OMA:H1-4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,156,329 bp[1] End 26,157,115 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,804,612 bp[2] End 23,806,541 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tendon of biceps brachii sural nerve epithelium of colon testicle bone marrow cell gonad corpus callosum secondary oocyte muscle of thigh Top expressed in genital tubercle ascending aorta aortic valve tail of embryo embryo muscle of thigh embryo granulocyte zygote morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding chromatin DNA binding protein binding RNA binding nucleotide binding double-stranded DNA binding calcium ion binding ATP binding GTP binding AMP binding dATP binding ADP binding nucleosomal DNA binding Cellular component nucleosome extracellular exosome nucleus chromosome Biological process regulation of transcription by RNA polymerase II histone H3-K4 trimethylation nucleosome assembly negative regulation of transcription by RNA polymerase II histone H3-K27 trimethylation regulation of transcription, DNA-templated chromosome condensation negative regulation of DNA recombination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3008 50709 Ensembl ENSG00000168298 ENSMUSG00000051627 UniProt P10412 P43274 RefSeq (mRNA) NM_005321 NM_015787 RefSeq (protein) NP_005312 NP_005312.1 NP_056602 Location (UCSC) Chr 6: 26.16 – 26.16 Mb Chr 13: 23.8 – 23.81 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[7]