HIST1H2AA

Histone H2A type 1-A is a protein that in humans is encoded by the HIST1H2AA gene.^[5][6]

AliasesH2AC1, H2AA, H2AFR, bA317E16.2, TH2A, histone cluster 1, H2aa, histone cluster 1 H2A family member a, HIST1H2AA, H2A clustered histone 1, HISTH2AA

External IDsOMIM: 613499; MGI: 2448297; HomoloGene: 108269; GeneCards: H2AC1; OMA:H2AC1 - orthologs

Chr.Chromosome 6 (human)^[1]

End25,726,562 bp^[1]

Quick facts H2AC1, Identifiers ...

H2AC1
Identifiers
Aliases	H2AC1, H2AA, H2AFR, bA317E16.2, TH2A, histone cluster 1, H2aa, histone cluster 1 H2A family member a, HIST1H2AA, H2A clustered histone 1, HISTH2AA
External IDs	OMIM: 613499; MGI: 2448297; HomoloGene: 108269; GeneCards: H2AC1; OMA:H2AC1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 25,726,063 bp[1] End 25,726,562 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 21,937,605 bp[2] End 21,937,997 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad left testis right testis liver right lobe of liver human kidney body of pancreas renal cortex respiratory system Top expressed in uterus genital tubercle spermatid mesencephalon tail of embryo embryo embryo bone marrow yolk sac thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity DNA binding Cellular component nucleosome nucleus chromosome extracellular exosome Biological process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221613 319169 Ensembl ENSG00000164508 ENSMUSG00000063021 UniProt Q96QV6 Q8CGP7 RefSeq (mRNA) NM_170745 NM_178183 RefSeq (protein) NP_734466 NP_835490 Location (UCSC) Chr 6: 25.73 – 25.73 Mb Chr 13: 21.94 – 21.94 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.^[6]