HIST1H2AJ

Histone H2A type 1-J is a protein that in humans is encoded by the HIST1H2AJ gene.^[5][6][7]

AliasesH2AC14, H2A/E, H2AFE, dJ160A22.4, histone cluster 1, H2aj, histone cluster 1 H2A family member j, H2A clustered histone 14, HIST1H2AJ

External IDsOMIM: 602791; MGI: 2448309; HomoloGene: 88882; GeneCards: H2AC14; OMA:H2AC14 - orthologs

Chr.Chromosome 6 (human)^[1]

End27,814,777 bp^[1]

Quick facts H2AC14, Identifiers ...

H2AC14
Identifiers
Aliases	H2AC14, H2A/E, H2AFE, dJ160A22.4, histone cluster 1, H2aj, histone cluster 1 H2A family member j, H2A clustered histone 14, HIST1H2AJ
External IDs	OMIM: 602791; MGI: 2448309; HomoloGene: 88882; GeneCards: H2AC14; OMA:H2AC14 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,814,302 bp[1] End 27,814,777 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,718,076 bp[2] End 23,718,474 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell testicle gonad epithelium of colon Achilles tendon tonsil mucosa of transverse colon ganglionic eminence blood sural nerve Top expressed in uterus bone marrow thymus yolk sac spleen embryo genital tubercle embryo lens granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein heterodimerization activity molecular function Cellular component nucleosome extracellular exosome nucleus chromosome Biological process chromatin organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8331 319173 Ensembl ENSG00000276368 ENSMUSG00000061991 UniProt Q99878 Q8CGP5 RefSeq (mRNA) NM_021066 NM_175661 RefSeq (protein) NP_066544 NP_783592 Location (UCSC) Chr 6: 27.81 – 27.81 Mb Chr 13: 23.72 – 23.72 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.^[7]