HIST1H2AK

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AK gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesH2AC15, H2A/d, H2AFD, histone cluster 1, H2ak, histone cluster 1 H2A family member k, HIST1H2AK, H2A clustered histone 15, H2AC11, H2AC14, H2AC17, H2AC16, H2AC13, H2A.1

External IDsOMIM: 602788; MGI: 2448287; HomoloGene: 134305; GeneCards: H2AC15; OMA:H2AC15 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts H2AC15, Available structures ...

H2AC15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QYL, 5KGF
Identifiers
Aliases	H2AC15, H2A/d, H2AFD, histone cluster 1, H2ak, histone cluster 1 H2A family member k, HIST1H2AK, H2A clustered histone 15, H2AC11, H2AC14, H2AC17, H2AC16, H2AC13, H2A.1
External IDs	OMIM: 602788; MGI: 2448287; HomoloGene: 134305; GeneCards: H2AC15; OMA:H2AC15 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,837,880 bp[1] End 27,838,375 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,865,450 bp[2] End 23,867,931 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle trachea vastus lateralis muscle thalamus spinal ganglia epithelium of bronchus paraflocculus of cerebellum middle frontal gyrus frontal pole bone marrow cell Top expressed in granulocyte bone marrow uterus embryo yolk sac secondary oocyte primary oocyte zygote lens quadriceps femoris muscle More reference expression data BioGPS n/a
Gene ontology Molecular function enzyme binding DNA binding protein binding protein heterodimerization activity Cellular component nucleosome extracellular exosome nucleus chromosome Biological process chromatin organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8330 319164 Ensembl ENSG00000275221 ENSMUSG00000069270 UniProt P0C0S8 C0HKE2 B2RVF0 C0HKE1 C0HKE3 C0HKE4 C0HKE5 C0HKE6 C0HKE7 C0HKE8 C0HKE9 RefSeq (mRNA) NM_003510 NM_178189 RefSeq (protein) NP_066408 NP_003505 NP_835496 NP_835495 NP_835494 NP_835491 NP_835489 NP_783591 NP_835493 NP_835496 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835489 NP_001171015 NP_835496 NP_835491 NP_835493 NP_835494 NP_835495 NP_835492 NP_783591 NP_835494 NP_835489 NP_835495 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835495 NP_835489 NP_835494 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835492 NP_835491 NP_835489 NP_835495 NP_835494 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835491 NP_835489 NP_835495 NP_835494 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_783591 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_001171015 NP_835493 NP_835496 NP_783591 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_001171015 NP_835493 NP_835496 Location (UCSC) Chr 6: 27.84 – 27.84 Mb Chr 13: 23.87 – 23.87 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.^[7]