HIST3H2A

Histone H2A type 3 is a protein that in humans is encoded by the HIST3H2A gene.^[5][6]

AliasesH2AW, histone cluster 3 H2A, HIST3H2A, H2A.W histone

External IDsOMIM: 615015; MGI: 2448458; HomoloGene: 137357; GeneCards: H2AW; OMA:H2AW - orthologs

Chr.Chromosome 1 (human)^[1]

End228,457,873 bp^[1]

Quick facts H2AW, Identifiers ...

H2AW
Identifiers
Aliases	H2AW, histone cluster 3 H2A, HIST3H2A, H2A.W histone
External IDs	OMIM: 615015; MGI: 2448458; HomoloGene: 137357; GeneCards: H2AW; OMA:H2AW - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 228,434,777 bp[1] End 228,457,873 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 58,845,511 bp[2] End 58,847,656 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum testicle ganglionic eminence left adrenal cortex apex of heart right adrenal gland right adrenal cortex gonad ventricular zone Top expressed in spermatocyte retinal pigment epithelium neural layer of retina medial ganglionic eminence lens epithelium of lens external carotid artery ciliary body olfactory bulb trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein heterodimerization activity protein binding Cellular component nucleosome extracellular exosome nucleus chromosome Biological process nucleosome disassembly UV-damage excision repair chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 92815 319162 Ensembl ENSG00000181218 ENSG00000284841 ENSMUSG00000078851 UniProt Q7L7L0 Q8BFU2 RefSeq (mRNA) NM_033445 NM_178218 RefSeq (protein) NP_254280 NP_835736 Location (UCSC) Chr 1: 228.43 – 228.46 Mb Chr 11: 58.85 – 58.85 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.^[6]