HIST1H2AD

Histone H2A type 1-D is a protein that in humans is encoded by the HIST1H2AD gene.^[5][6][7]

AliasesH2AC7, H2A.3, H2A/g, H2AFG, histone cluster 1, H2ad, histone cluster 1 H2A family member d, H2A clustered histone 7, HIST1H2AD

External IDsOMIM: 602792; MGI: 2448306; HomoloGene: 137350; GeneCards: H2AC7; OMA:H2AC7 - orthologs

Chr.Chromosome 6 (human)^[1]

End26,199,293 bp^[1]

Quick facts H2AC7, Identifiers ...

H2AC7
Identifiers
Aliases	H2AC7, H2A.3, H2A/g, H2AFG, histone cluster 1, H2ad, histone cluster 1 H2A family member d, H2A clustered histone 7, HIST1H2AD
External IDs	OMIM: 602792; MGI: 2448306; HomoloGene: 137350; GeneCards: H2AC7; OMA:H2AC7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,198,784 bp[1] End 26,199,293 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,935,109 bp[2] End 23,935,581 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell testicle corpus callosum gonad Achilles tendon epithelium of colon blood tonsil granulocyte vagina Top expressed in uterus genital tubercle embryo embryo bone marrow mesencephalon tail of embryo spermatid yolk sac blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein heterodimerization activity molecular function Cellular component nucleosome extracellular exosome nucleus chromosome Biological process chromatin organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3013 319172 Ensembl ENSG00000196866 ENSMUSG00000061615 UniProt P20671 C0HKE2 B2RVF0 C0HKE1 C0HKE3 C0HKE4 C0HKE5 C0HKE6 C0HKE7 C0HKE8 C0HKE9 RefSeq (mRNA) NM_021065 NM_175660 RefSeq (protein) NP_066409 NP_835496 NP_835495 NP_835494 NP_835491 NP_835489 NP_783591 NP_835493 NP_835496 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835489 NP_001171015 NP_835496 NP_835491 NP_835493 NP_835494 NP_835495 NP_835492 NP_783591 NP_835494 NP_835489 NP_835495 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835495 NP_835489 NP_835494 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835492 NP_835491 NP_835489 NP_835495 NP_835494 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835491 NP_835489 NP_835495 NP_835494 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_783591 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_001171015 NP_835493 NP_835496 NP_783591 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_001171015 NP_835493 NP_835496 Location (UCSC) Chr 6: 26.2 – 26.2 Mb Chr 13: 23.94 – 23.94 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.^[7]