H2AFJ

Histone H2A.J is a protein that in humans is encoded by the H2AFJ gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesH2AJ, H2AFJ, H2A.J histone, H2A histone family member J

External IDsMGI: 3606192; HomoloGene: 128575; GeneCards: H2AJ; OMA:H2AJ - orthologs

Chr.Chromosome 12 (human)^[1]

Quick facts H2AJ, Available structures ...

H2AJ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EDU
Identifiers
Aliases	H2AJ, H2AFJ, H2A.J histone, H2A histone family member J
External IDs	MGI: 3606192; HomoloGene: 128575; GeneCards: H2AJ; OMA:H2AJ - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.3 Start 14,774,405 bp[1] End 14,778,002 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 G1 Start 136,785,242 bp[2] End 136,787,072 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis olfactory zone of nasal mucosa mucosa of transverse colon tibial arteries left coronary artery thoracic aorta right coronary artery ascending aorta Descending thoracic aorta Top expressed in Paneth cell internal carotid artery external carotid artery lacrimal gland crypt of lieberkuhn of small intestine fossa condyle blood hair follicle submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein heterodimerization activity DNA binding molecular function Cellular component extracellular exosome chromosome nucleosome nucleus Biological process chromatin organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55766 232440 Ensembl ENSG00000246705 ENSMUSG00000060032 UniProt Q9BTM1 Q8R1M2 RefSeq (mRNA) NM_018267 NM_177925 NM_177688 RefSeq (protein) NP_808760 NP_808356 Location (UCSC) Chr 12: 14.77 – 14.78 Mb Chr 6: 136.79 – 136.79 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member.^[5]