HIST1H2BA

Histone H2B type 1-A is a protein that in humans is encoded by the HIST1H2BA gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesH2BC1, H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3, TH2B, histone cluster 1, H2ba, histone cluster 1 H2B family member a, hTSH2B, HIST1H2BA, H2B clustered histone 1

External IDsOMIM: 609904; MGI: 2448375; HomoloGene: 69356; GeneCards: H2BC1; OMA:H2BC1 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts H2BC1, Available structures ...

H2BC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WKJ
Identifiers
Aliases	H2BC1, H2BFU, STBP, TSH2B, TSH2B.1, bA317E16.3, TH2B, histone cluster 1, H2ba, histone cluster 1 H2B family member a, hTSH2B, HIST1H2BA, H2B clustered histone 1
External IDs	OMIM: 609904; MGI: 2448375; HomoloGene: 69356; GeneCards: H2BC1; OMA:H2BC1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 25,726,777 bp[1] End 25,727,345 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 24,117,756 bp[2] End 24,118,139 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle left testis right testis sperm kidney human kidney right lobe of liver metanephros respiratory system Top expressed in spermatocyte spermatid secondary oocyte primary oocyte zygote embryo embryo testicle genital tubercle tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function protein heterodimerization activity DNA binding histone binding molecular function Cellular component nucleosome extrinsic component of plasma membrane nucleus chromosome nucleoplasm DNA packaging complex Biological process mononuclear cell migration nucleosome assembly positive regulation of binding nucleosome disassembly plasminogen activation inflammatory response chromatin organization protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 255626 319177 Ensembl ENSG00000146047 ENSMUSG00000050799 UniProt Q96A08 P70696 RefSeq (mRNA) NM_170610 NM_175663 RefSeq (protein) NP_733759 NP_783594 Location (UCSC) Chr 6: 25.73 – 25.73 Mb Chr 13: 24.12 – 24.12 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.^[7]