HIST1H2BN

Histone H2B type 1-N is a protein that in humans is encoded by the HIST1H2BN gene.^[5][6][7]

AliasesH2BC15, H2B/d, H2BFD, histone cluster 1, H2bn, histone cluster 1 H2B family member n, H2B clustered histone 15, HIST1H2BN

External IDsOMIM: 602801; MGI: 2448404; HomoloGene: 135961; GeneCards: H2BC15; OMA:H2BC15 - orthologs

Chr.Chromosome 6 (human)^[1]

End27,855,709 bp^[1]

Quick facts H2BC15, Identifiers ...

H2BC15
Identifiers
Aliases	H2BC15, H2B/d, H2BFD, histone cluster 1, H2bn, histone cluster 1 H2B family member n, H2B clustered histone 15, HIST1H2BN
External IDs	OMIM: 602801; MGI: 2448404; HomoloGene: 135961; GeneCards: H2BC15; OMA:H2BC15 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,838,545 bp[1] End 27,855,709 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 21,906,214 bp[2] End 21,906,737 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell epithelium of colon monocyte Achilles tendon stromal cell of endometrium tonsil ventricular zone C1 segment striated muscle tissue skeletal muscle tissue Top expressed in spermatid genital tubercle spermatocyte tail of embryo uterus zygote embryo embryo bone marrow morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein heterodimerization activity Cellular component chromosome nucleosome extracellular exosome nucleus nucleoplasm cytosol Biological process nucleosome assembly protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8341 319186 Ensembl ENSG00000233822 ENSMUSG00000114279 UniProt Q99877 P10854 RefSeq (mRNA) NM_003520 NM_178200 RefSeq (protein) NP_003511 NP_835507 Location (UCSC) Chr 6: 27.84 – 27.86 Mb Chr 13: 21.91 – 21.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.^[7]