HIST1H4G

Histone H4-like protein type G is a protein that in humans is encoded by the HIST1H4G gene.^[3][4][5]

AliasesH4C7, H4/l, H4FL, histone cluster 1, H4g, histone cluster 1 H4 family member g, H4 clustered histone 7, HIST1H4G

External IDsOMIM: 602832; HomoloGene: 48222; GeneCards: H4C7; OMA:H4C7 - orthologs

Chr.Chromosome 6 (human)^[1]

End26,246,996 bp^[1]

Quick facts H4C7, Identifiers ...

H4C7
Identifiers
Aliases	H4C7, H4/l, H4FL, histone cluster 1, H4g, histone cluster 1 H4 family member g, H4 clustered histone 7, HIST1H4G
External IDs	OMIM: 602832; HomoloGene: 48222; GeneCards: H4C7; OMA:H4C7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,246,611 bp[1] End 26,246,996 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle optic nerve deltoid muscle cell somatic cell mononuclear cell cerebral cortex monocyte rectum small intestine n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein heterodimerization activity DNA binding histone binding molecular function Cellular component nucleosome nucleus chromosome Biological process nucleosome assembly biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8369 n/a Ensembl ENSG00000275663 n/a UniProt Q99525 n/a RefSeq (mRNA) NM_003547 n/a RefSeq (protein) NP_003538 n/a Location (UCSC) Chr 6: 26.25 – 26.25 Mb n/a PubMed search [2] n/a
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[5]