HBQ1

Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.^[5][6]

AliasesHBQ1, HBQ, hemoglobin subunit theta 1

External IDsOMIM: 142240; MGI: 3613460; HomoloGene: 3895; GeneCards: HBQ1; OMA:HBQ1 - orthologs

Chr.Chromosome 16 (human)^[1]

End181,179 bp^[1]

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HBQ1
Identifiers
Aliases	HBQ1, HBQ, hemoglobin subunit theta 1
External IDs	OMIM: 142240; MGI: 3613460; HomoloGene: 3895; GeneCards: HBQ1; OMA:HBQ1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 180,459 bp[1] End 181,179 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A4 Start 32,236,965 bp[2] End 32,237,784 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood testicle monocyte gonad trabecular bone anterior cingulate cortex nucleus accumbens bone marrow amygdala Brodmann area 9 Top expressed in bone marrow yolk sac embryo spleen embryo lobe of liver placenta primary visual cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding protein binding heme binding metal ion binding oxygen carrier activity peroxidase activity haptoglobin binding organic acid binding Cellular component hemoglobin complex haptoglobin-hemoglobin complex Biological process oxygen transport hydrogen peroxide catabolic process protein heterooligomerization cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3049 544763 Ensembl ENSG00000086506 ENSMUSG00000073063 UniProt P09105 Q3U0A6 RefSeq (mRNA) NM_005331 NM_001033981 RefSeq (protein) NP_005322 NP_001029153 Location (UCSC) Chr 16: 0.18 – 0.18 Mb Chr 11: 32.24 – 32.24 Mb PubMed search [3] [4]
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Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.^[6]