HBXIP

Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesLAMTOR5, HBXIP, XIP, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

External IDsOMIM: 608521; MGI: 1915826; HomoloGene: 4668; GeneCards: LAMTOR5; OMA:LAMTOR5 - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts LAMTOR5, Available structures ...

LAMTOR5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MS6, 3MSH
Identifiers
Aliases	LAMTOR5, HBXIP, XIP, late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
External IDs	OMIM: 608521; MGI: 1915826; HomoloGene: 4668; GeneCards: LAMTOR5; OMA:LAMTOR5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 110,401,249 bp[1] End 110,407,942 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.3 Start 107,186,174 bp[2] End 107,191,398 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule islet of Langerhans palpebral conjunctiva monocyte human kidney apex of heart muscle of thigh left ventricle anterior pituitary glomerulus Top expressed in right kidney yolk sac facial motor nucleus medial ganglionic eminence proximal tubule human kidney endocardial cushion embryo anterior horn of spinal cord embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity protein binding molecular adaptor activity Cellular component cytoplasm cytosol Ragulator complex lysosomal membrane lysosome Biological process regulation of cell size negative regulation of cysteine-type endopeptidase activity involved in apoptotic process viral genome replication response to virus negative regulation of apoptotic process protein localization to lysosome cellular response to amino acid stimulus positive regulation of TOR signaling regulation of macroautophagy positive regulation of TORC1 signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10542 68576 Ensembl ENSG00000134248 ENSMUSG00000087260 UniProt O43504 Q9D1L9 RefSeq (mRNA) NM_006402 NM_001382293 NM_026774 RefSeq (protein) NP_006393 NP_001369222 NP_006393.2 NP_081050 Location (UCSC) Chr 1: 110.4 – 110.41 Mb Chr 3: 107.19 – 107.19 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.^[6]