PPP1R11

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.^[5][6][7]

AliasesPPP1R11, HCG-V, HCGV, IPP3, TCTE5, TCTEX5, CFAP255, protein phosphatase 1 regulatory inhibitor subunit 11

External IDsOMIM: 606670; MGI: 1923747; HomoloGene: 32520; GeneCards: PPP1R11; OMA:PPP1R11 - orthologs

Chr.Chromosome 6 (human)^[1]

End30,070,333 bp^[1]

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PPP1R11
Identifiers
Aliases	PPP1R11, HCG-V, HCGV, IPP3, TCTE5, TCTEX5, CFAP255, protein phosphatase 1 regulatory inhibitor subunit 11
External IDs	OMIM: 606670; MGI: 1923747; HomoloGene: 32520; GeneCards: PPP1R11; OMA:PPP1R11 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 30,066,709 bp[1] End 30,070,333 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 19.16 cM Start 37,259,248 bp[2] End 37,262,633 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum superior frontal gyrus smooth muscle tissue mucosa of transverse colon granulocyte duodenum blood epithelium of colon primary visual cortex body of stomach Top expressed in seminiferous tubule spermatid spermatocyte interventricular septum neural layer of retina yolk sac dentate gyrus of hippocampal formation granule cell blastocyst muscle of thigh primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase inhibitor activity protein binding protein phosphatase 1 binding protein serine/threonine phosphatase inhibitor activity ubiquitin protein ligase activity transferase activity Cellular component cytoplasm protein phosphatase type 1 complex nucleus Biological process negative regulation of phosphoprotein phosphatase activity defense response to Gram-positive bacterium protein ubiquitination ubiquitin-dependent protein catabolic process negative regulation of protein dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6992 76497 Ensembl ENSG00000234058 ENSG00000236560 ENSG00000237829 ENSG00000204619 ENSG00000237403 ENSG00000233314 ENSG00000206501 ENSG00000227720 ENSMUSG00000036398 UniProt O60927 Q8K1L5 RefSeq (mRNA) NM_021959 NM_170781 NM_029632 RefSeq (protein) NP_068778 NP_068778.1 NP_083908 Location (UCSC) Chr 6: 30.07 – 30.07 Mb Chr 17: 37.26 – 37.26 Mb PubMed search [3] [4]
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This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1.

The gene is located within the major histocompatibility complex class I region on chromosome 6.^[7]