HCLS1

HCLS1
Identifiers
Aliases	HCLS1, CTTNL, HS1, lckBP1, p75, hematopoietic cell-specific Lyn substrate 1
External IDs	OMIM: 601306; MGI: 104568; HomoloGene: 38034; GeneCards: HCLS1; OMA:HCLS1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	36,783,574 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; appendix; ; bone marrow cell; ; lymph node; ; right lung; ; trabecular bone; ; upper lobe of left lung; ; gallbladder;
	Top expressed in
	granulocyte; ; mesenteric lymph nodes; ; thymus; ; spleen; ; neural layer of retina; ; bone marrow; ; stroma of bone marrow; ; ankle joint; ; tibiofemoral joint; ; blood;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding; actin binding; protein kinase binding; protein-containing complex binding;
Cellular component	cytoplasm; membrane; transcription regulator complex; mitochondrion; nucleus; cytosol; plasma membrane;
Biological process	positive regulation of protein kinase B signaling; intracellular signal transduction; regulation of transcription, DNA-templated; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of macrophage differentiation; negative regulation of transcription by RNA polymerase II; cellular response to cytokine stimulus; positive regulation of peptidyl-serine phosphorylation; regulation of actin filament polymerization; actin filament polymerization; positive regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of granulocyte differentiation; erythrocyte differentiation; negative regulation of leukocyte apoptotic process; response to hormone; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of actin cytoskeleton reorganization; positive regulation of transcription by RNA polymerase II; positive regulation of protein import into nucleus; positive regulation of DNA-binding transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	3059
	15163
	n/a
	ENSMUSG00000022831
	P14317
	P49710
	NM_005335; NM_001292041
	NM_008225
	NP_001278970; NP_005326
	NP_032251
	Wikidata
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