HCN1

HCN1
Identifiers
Aliases	HCN1, BCNG-1, BCNG1, EIEE24, HAC-2, hyperpolarization activated cyclic nucleotide gated potassium channel 1, GEFSP10, DEE24
External IDs	OMIM: 602780; MGI: 1096392; GeneCards: HCN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3U0Z
Gene location (Human)
Chr.	Chromosome 5 (human)
End	45,696,498 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	118,123,954 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; primary visual cortex; ; trigeminal ganglion; ; Brodmann area 46; ; spinal ganglia; ; prefrontal cortex; ; superior frontal gyrus; ; middle temporal gyrus; ; parietal lobe;
	Top expressed in
	subiculum; ; medial vestibular nucleus; ; pontine nuclei; ; deep cerebellar nuclei; ; cerebellar vermis; ; facial motor nucleus; ; lobe of cerebellum; ; lumbar spinal ganglion; ; anterior horn of spinal cord; ; inferior colliculi;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; intracellular cAMP-activated cation channel activity; identical protein binding; voltage-gated sodium channel activity; ion channel activity; potassium channel activity; sodium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity; voltage-gated cation channel activity; cAMP binding; protein binding;
Cellular component	axon; membrane; dendrite; plasma membrane; integral component of membrane; HCN channel complex; integral component of plasma membrane;
Biological process	transmembrane transport; retinal cone cell development; regulation of ion transmembrane transport; apical protein localization; ion transport; sodium ion transport; regulation of membrane potential; sodium ion transmembrane transport; potassium ion transmembrane transport; potassium ion transport; protein homotetramerization; cellular response to cAMP;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	348980
	15165
	ENSG00000164588
	ENSMUSG00000021730
	O60741
	O88704
	NM_021072
	NM_010408
	NP_066550
	NP_034538
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.^[5]^[6]^[7]^[8]