HGFAC

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesHGFAC, HGFA, HGF activator

External IDsOMIM: 604552; MGI: 1859281; HomoloGene: 1170; GeneCards: HGFAC; OMA:HGFAC - orthologs

Chr.Chromosome 4 (human)^[1]

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HGFAC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YBW, 1YC0, 2R0K, 2R0L, 2WUB, 2WUC, 3K2U
Identifiers
Aliases	HGFAC, HGFA, HGF activator
External IDs	OMIM: 604552; MGI: 1859281; HomoloGene: 1170; GeneCards: HGFAC; OMA:HGFAC - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 3,441,968 bp[1] End 3,449,486 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B2 Start 35,198,853 bp[2] End 35,205,805 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right testis left testis right hemisphere of cerebellum right uterine tube ganglionic eminence testicle right frontal lobe ventricular zone anterior pituitary Top expressed in left lobe of liver crypt of lieberkuhn of small intestine large intestine islet of Langerhans left colon duodenum pyloric antrum fetal liver hematopoietic progenitor cell right kidney jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component extracellular region extracellular space cytosol rough endoplasmic reticulum Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3083 54426 Ensembl ENSG00000109758 ENSMUSG00000029102 UniProt Q04756 Q9R098 RefSeq (mRNA) NM_001297439 NM_001528 NM_019447 RefSeq (protein) NP_001284368 NP_001519 NP_062320 Location (UCSC) Chr 4: 3.44 – 3.45 Mb Chr 5: 35.2 – 35.21 Mb PubMed search [3] [4]
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The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.^[7]