HIP1R

Huntingtin-interacting protein 1-related protein is a protein that in humans is encoded by the HIP1R gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesHIP1R, HIP12, HIP3, ILWEQ, huntingtin interacting protein 1 related

External IDsOMIM: 605613; MGI: 1352504; HomoloGene: 78348; GeneCards: HIP1R; OMA:HIP1R - orthologs

Chr.Chromosome 12 (human)^[1]

Quick facts Available structures, PDB ...

HIP1R
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R0D
Identifiers
Aliases	HIP1R, HIP12, HIP3, ILWEQ, huntingtin interacting protein 1 related
External IDs	OMIM: 605613; MGI: 1352504; HomoloGene: 78348; GeneCards: HIP1R; OMA:HIP1R - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 122,834,453 bp[1] End 122,862,961 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 124,111,691 bp[2] End 124,143,621 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment inferior olivary nucleus skin of leg right frontal lobe body of pancreas amygdala skin of abdomen anterior pituitary dorsal motor nucleus of vagus nerve hypothalamus Top expressed in transitional epithelium of urinary bladder saccule epithelium of stomach granulocyte otic placode otic vesicle hair follicle lip submandibular gland motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding phospholipid binding phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding SH3 domain binding clathrin binding clathrin light chain binding clathrin adaptor activity protein homodimerization activity phosphatidylinositol-3,4-bisphosphate binding protein heterodimerization activity actin filament binding phosphatidylinositol-3,5-bisphosphate binding identical protein binding Cellular component perinuclear region of cytoplasm clathrin-coated pit cytoskeleton clathrin-coated vesicle membrane intracellular membrane-bounded organelle endomembrane system membrane cytoplasmic vesicle clathrin-coated vesicle cytoplasm mitochondrion cytosol cell cortex postsynaptic density apical plasma membrane ruffle membrane dendrite cytoplasm soma dendritic spine synaptic membrane AP-2 adaptor complex actin cortical patch Biological process endocytosis receptor-mediated endocytosis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of endocytosis negative regulation of actin filament polymerization positive regulation of protein binding regulation of actin cytoskeleton organization negative regulation of Arp2/3 complex-mediated actin nucleation positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of epidermal growth factor receptor signaling pathway clathrin coat assembly protein stabilization digestive system development regulation of gastric acid secretion membrane organization positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway positive regulation of clathrin coat assembly positive regulation of platelet-derived growth factor receptor-beta signaling pathway regulation of clathrin-dependent endocytosis actin filament organization positive regulation of receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9026 29816 Ensembl ENSG00000130787 ENSMUSG00000000915 UniProt O75146 Q9JKY5 RefSeq (mRNA) NM_001303097 NM_001303099 NM_003959 NM_145070 RefSeq (protein) NP_001290026 NP_001290028 NP_003950 NP_659507 Location (UCSC) Chr 12: 122.83 – 122.86 Mb Chr 5: 124.11 – 124.14 Mb PubMed search [3] [4]
Wikidata
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