HLA-DOA

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.^[5][6]

PDBHuman UniProt search: PDBe RCSB

AliasesHLA-DOA, HLA-DNA, HLA-DZA, HLADZ, major histocompatibility complex, class II, DO alpha

External IDsOMIM: 142930; MGI: 95924; HomoloGene: 1601; GeneCards: HLA-DOA; OMA:HLA-DOA - orthologs

Chr.Chromosome 6 (human)^[1]

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HLA-DOA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4I0P
Identifiers
Aliases	HLA-DOA, HLA-DNA, HLA-DZA, HLADZ, major histocompatibility complex, class II, DO alpha
External IDs	OMIM: 142930; MGI: 95924; HomoloGene: 1601; GeneCards: HLA-DOA; OMA:HLA-DOA - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 33,004,182 bp[1] End 33,009,591 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,311,314 bp[2] End 34,314,208 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node appendix granulocyte spleen gallbladder monocyte blood tonsil upper lobe of left lung right lung Top expressed in mesenteric lymph nodes spleen blood thymus morula submandibular gland subcutaneous adipose tissue embryo primary oocyte embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MHC class II receptor activity protein binding MHC class II protein complex binding Cellular component integral component of membrane lysosomal membrane endosome plasma membrane lysosome MHC class II protein complex endosome membrane membrane Biological process antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II immune response negative regulation of antigen processing and presentation of peptide antigen via MHC class II regulation of T cell differentiation immune system process signal transduction adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3111 15001 Ensembl ENSG00000204252 ENSG00000230141 ENSG00000232962 ENSG00000235744 ENSG00000231558 ENSG00000206292 ENSG00000232957 ENSMUSG00000024334 UniProt P06340 n/a RefSeq (mRNA) NM_002119 NM_015851 NM_008206 RefSeq (protein) NP_002110 n/a Location (UCSC) Chr 6: 33 – 33.01 Mb Chr 17: 34.31 – 34.31 Mb PubMed search [3] [4]
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HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.^[6]