HLA-DOB

HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.^[5]

PDBHuman UniProt search: PDBe RCSB

AliasesHLA-DOB, DOB, major histocompatibility complex, class II, DO beta, HLA_DOB

External IDsOMIM: 600629; MGI: 95925; HomoloGene: 1602; GeneCards: HLA-DOB; OMA:HLA-DOB - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts Available structures, PDB ...

HLA-DOB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4I0P
Identifiers
Aliases	HLA-DOB, DOB, major histocompatibility complex, class II, DO beta, HLA_DOB
External IDs	OMIM: 600629; MGI: 95925; HomoloGene: 1602; GeneCards: HLA-DOB; OMA:HLA-DOB - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 32,812,763 bp[1] End 32,820,466 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 17.98 cM Start 34,457,877 bp[2] End 34,473,388 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node spleen appendix granulocyte bone marrow cell blood tonsil testicle monocyte rectum Top expressed in mesenteric lymph nodes spleen blood submandibular gland subcutaneous adipose tissue white pulp thymus granulocyte embryo bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MHC class II receptor activity MHC class II protein complex binding Cellular component lysosomal membrane endosome membrane lysosome membrane endosome integral component of membrane intracellular anatomical structure MHC class II protein complex Biological process negative regulation of antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation immune system process antigen processing and presentation of exogenous peptide antigen via MHC class II immune response signal transduction adaptive immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3112 15002 Ensembl ENSG00000243496 ENSG00000241910 ENSG00000243612 ENSG00000239457 ENSG00000241386 ENSG00000241106 ENSMUSG00000041538 UniProt P13765 n/a RefSeq (mRNA) NM_002120 NM_010389 RefSeq (protein) NP_002111 n/a Location (UCSC) Chr 6: 32.81 – 32.82 Mb Chr 17: 34.46 – 34.47 Mb PubMed search [3] [4]
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HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.^[5]