HLA-DR10
Serotype
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HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.
 | |
major histocompatibility complex, class II, DR10 | |
| Haplotypes groups | DQA*01:DRB1*1001 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | HLA-DRA[permanent dead link] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1001 |
| Symbol(s) | HLA-DRB1[permanent dead link] |
| EBI-HLA | DRB1*1001 |
| Shared data | |
| Locus | chr.6 6p21.31 |
Serology
| DRB1* | DR10 | DR1 | Sample | |
| allele | % | % | % | size (N) |
| 1001 | 90 | 4 | 894 | |
The serological reaction of DR10 is relatively good.
Disease associations
By serotype
DR10 serotype or cognate alleles are associated with: Lichen planus[2]
By allele
DRB1*1001 is associated with ovarian cancer[3] and invasive squamous cell cervical cancer (SCC)[4]
Extended linkage
DRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis[5] The primary involvement appears to be DR10.