HMGN3

High mobility group nucleosome-binding domain-containing protein 3 is a protein that in humans is encoded by the HMGN3 gene.^[5][6][7]

AliasesHMGN3, PNAS-25, TRIP7, PNAS-24, high mobility group nucleosomal binding domain 3

External IDsOMIM: 604502; MGI: 2138069; HomoloGene: 130417; GeneCards: HMGN3; OMA:HMGN3 - orthologs

Chr.Chromosome 6 (human)^[1]

End79,234,738 bp^[1]

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HMGN3
Identifiers
Aliases	HMGN3, PNAS-25, TRIP7, PNAS-24, high mobility group nucleosomal binding domain 3
External IDs	OMIM: 604502; MGI: 2138069; HomoloGene: 130417; GeneCards: HMGN3; OMA:HMGN3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.1 Start 79,201,245 bp[1] End 79,234,738 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E2 Start 82,992,001 bp[2] End 83,028,738 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell endothelial cell palpebral conjunctiva right uterine tube parietal pleura ventricular zone mucosa of paranasal sinus visceral pleura hair follicle germinal epithelium Top expressed in lens conjunctival fornix ciliary body epithelium of lens saccule islet of Langerhans condyle olfactory epithelium fossa ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleosomal DNA binding DNA binding chromatin binding thyroid hormone receptor binding Cellular component chromatin nucleus nucleoplasm cytosol Biological process regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of transcription by RNA polymerase II biological process chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9324 94353 Ensembl ENSG00000118418 ENSMUSG00000066456 UniProt Q15651 Q9DCB1 RefSeq (mRNA) NM_001201362 NM_001201363 NM_004242 NM_138730 NM_001318884 NM_001318885 NM_001318886 NM_001318887 NM_001318888 NM_026122 NM_175074 RefSeq (protein) NP_001188291 NP_001188292 NP_001305813 NP_001305814 NP_001305815 NP_001305816 NP_001305817 NP_004233 NP_620058 NP_080398 NP_778249 Location (UCSC) Chr 6: 79.2 – 79.23 Mb Chr 9: 82.99 – 83.03 Mb PubMed search [3] [4]
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Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene.^[7]