DEFA4

DEFA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZMM
Identifiers
Aliases	DEFA4, DEF4, HNP-4, HP-4, HP4, defensin alpha 4
External IDs	OMIM: 601157; MGI: 3711900; HomoloGene: 48059; GeneCards: DEFA4; OMA:DEFA4 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	6,938,306 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	21,556,012 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; bone marrow cell; ; monocyte; ; blood; ; granulocyte; ; spleen; ; right lung; ; upper lobe of left lung; ; placenta; ; right lobe of liver;
	Top expressed in
	ileum; ; jejunum; ; duodenum; ; embryo; ; colon; ; pancreas; ; thymus; ; esophagus; ; liver; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity;
Cellular component	Golgi lumen; extracellular region; azurophil granule; extracellular space; specific granule lumen;
Biological process	defense response; defense response to bacterium; neutrophil degranulation; innate immune response; antimicrobial humoral immune response mediated by antimicrobial peptide; T cell chemotaxis; antimicrobial humoral response; killing of cells of other organism; defense response to fungus; innate immune response in mucosa; antibacterial humoral response; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; membrane disruption in other organism; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	1669
	100041688
	ENSG00000164821; ENSG00000285318
	ENSMUSG00000061845
	P12838
	E9QLQ1
	NM_001925
	NM_001177481
	NP_001916
	NP_001170952
	Wikidata
View/Edit Human	View/Edit Mouse

Defensin, alpha 4 (DEFA4), also known as neutrophil defensin 4 or HNP4, is a human defensin peptide that is encoded by the DEFA4 gene.^[5]^[6] HNP4 is expressed in the granules of the neutrophil where it defends the host against bacteria^[7] and viruses.^[8]