HNRNPAB

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRNPAB, is a protein which in humans is encoded by the HNRNPAB gene.[5] Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B,[6] it is not a member of the HNRNP A/B subfamily of HNRNPs, but groups together closely with HNRNPD/AUF1 and HNRNPDL.[7][8]

PDBOrtholog search: PDBe RCSB
AliasesHNRNPAB, ABBP1, HNRPAB, heterogeneous nuclear ribonucleoprotein A/B
Quick facts Available structures, PDB ...
HNRNPAB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNRNPAB, ABBP1, HNRPAB, heterogeneous nuclear ribonucleoprotein A/B
External IDsOMIM: 602688; MGI: 1330294; HomoloGene: 74950; GeneCards: HNRNPAB; OMA:HNRNPAB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031266
NM_004499

NM_001048061
NM_010448

RefSeq (protein)

NP_004490
NP_112556

NP_001041526
NP_034578

Location (UCSC)Chr 5: 178.2 – 178.21 MbChr 11: 51.49 – 51.5 Mb
PubMed search[3][4]
Wikidata
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Function

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]

Interactions

HNRNPAB has been shown to interact with TP63.[9]

References

Further reading

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