HOT-2

Pharmaceutical compound From Wikipedia, the free encyclopedia

HOT-2, also known as 4-ethylthio-2,5-dimethoxy-N-hydroxyphenethylamine or as N-hydroxy-2C-T-2, is a psychedelic drug of the phenethylamine, 2C, and HOT-x families.[1] It is the N-hydroxy derivative of 2C-T-2.[1] The drug is taken orally.[1]

Other names4-Ethylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-ethylthio-N-hydroxyphenethylamine; N-Hydroxy-2C-T-2; N-OH-2C-T-2
Routes of
administrationOral[1]
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Quick facts Clinical data, Other names ...
HOT-2
Clinical data
Other names4-Ethylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-ethylthio-N-hydroxyphenethylamine; N-Hydroxy-2C-T-2; N-OH-2C-T-2
Routes of
administration		Oral[1]
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Pharmacokinetic data
MetabolitesPossibly 2C-T-2[1][2]
Onset of action30–40 minutes[1]
Peak: 2 hours[1]
Duration of action6–10 hours[1]
Identifiers
  • 2-[4-(ethylsulfanyl)-2,5-dimethoxyphenyl]-N-hydroxyethan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H19NO3S
Molar mass257.35 g·mol−1
3D model (JSmol)
Melting point122 °C (252 °F)
  • CCSc1cc(OC)c(cc1OC)CCNO
  • InChI=1S/C12H19NO3S/c1-4-17-12-8-10(15-2)9(5-6-13-14)7-11(12)16-3/h7-8,13-14H,4-6H2,1-3H3 checkY
  • Key:XGFJCRNRWOXGQM-UHFFFAOYSA-N checkY
  (verify)
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Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists HOT-2's dose range as 10 to 18 mg orally and its duration as 6 to 10 hours.[1] The drug's onset is 30 to 40 minutes and peak effects occur after 2 hours.[1] HOT-2's properties are very similar to those of 2C-T-2, which has a dose of 12 to 25 mg orally, a duration of 6 to 8 hours, and an onset of less than 1 hour with a time to peak of 1 to 2 hours.[1][2] HOT-2 may act as a prodrug of 2C-T-2.[2]

The effects of HOT-2 have been reported to include some psychedelic visuals like perceptual movement, flowing, and shimmering, increased energy, euphoria, uncomfortableness, easier or more difficult communication, some difficulty concentrating and mental confusion, increased heart rate and blood pressure, and no body load.[1] Shulgin said of HOT-2 that it "seems to be a well tolerated, and generally pleasant material, with a mixture of sensory as well as insightful aspects. Something for everyone."[1]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Chemistry

Synthesis

The chemical synthesis of HOT-2 has been described.[1]

Analogues

Analogues of HOT-2 include 2C-T-2, HOT-7 (N-hydroxy-2C-T-7), and HOT-17 (N-hydroxy-2C-T-17), among others.[1]

History

HOT-2 was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1]

Society and culture

Canada

HOT-2 is a controlled substance in Canada under phenethylamine blanket-ban language.[3]

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.[4]

See also

References

External links

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