HOT-7

Pharmaceutical compound From Wikipedia, the free encyclopedia

HOT-7, also known as 4-propylthio-2,5-dimethoxy-N-hydroxyphenethylamine or as N-hydroxy-2C-T-7, is a psychedelic drug of the phenethylamine, 2C, and HOT-x families.[1] It is the N-hydroxy derivative of 2C-T-7.[1] The drug is taken orally.[1]

Other names4-Propylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-propylthio-N-hydroxyphenethylamine; N-Hydroxy-2C-T-7; N-OH-2C-T-7
Routes of
administrationOral[1]
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Quick facts Clinical data, Other names ...
HOT-7
Clinical data
Other names4-Propylthio-2,5-dimethoxy-N-hydroxyphenethylamine; 2,5-Dimethoxy-4-propylthio-N-hydroxyphenethylamine; N-Hydroxy-2C-T-7; N-OH-2C-T-7
Routes of
administration		Oral[1]
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Pharmacokinetic data
MetabolitesPossibly 2C-T-7[1][2]
Onset of actionUnknown[1]
Duration of action6–8 hours[1]
Identifiers
  • 2-[2,5-Dimethoxy-4-(propylsulfanyl)phenyl]-N-hydroxyethan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H21NO3S
Molar mass271.38 g·mol−1
3D model (JSmol)
  • COc1cc(SCCC)c(cc1CCNO)OC
  • InChI=1S/C13H21NO3S/c1-4-7-18-13-9-11(16-2)10(5-6-14-15)8-12(13)17-3/h8-9,14-15H,4-7H2,1-3H3 checkY
  • Key:ASTNLROMDNGJLS-UHFFFAOYSA-N checkY
  (verify)
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Use and effects

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists HOT-7's dose range as 15 to 20 mg orally and its duration as 6 to 8 hours.[1] The drug's onset and peak of effects were not described.[1] HOT-7's properties are similar to those of 2C-T-7, which has a dose of 10 to 30 mg orally and a duration of 8 to 15 hours, although HOT-7 may have a somewhat shorter duration.[1][2] HOT-7 may act as a prodrug of 2C-T-7.[2]

The effects of HOT-7 have been reported to include being "quite psychedelic", very rich in closed-eye imagery, not as much in terms of open-eye visuals, very good for interpretive and conceptual thinking, emotional changes, feeling "smoothly stoned", lightheadedness, alcohol-like tipsiness and wooziness, social avoidance, and gastrointestinal disturbances.[1]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Chemistry

Synthesis

The chemical synthesis of HOT-7 has been described.[1]

Analogues

Analogues of HOT-7 include 2C-T-7, HOT-2 (N-hydroxy-2C-T-2), and HOT-17 (N-hydroxy-2C-T-17), among others.[1]

History

HOT-7 was first described in the literature by Alexander Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1]

Society and culture

Canada

HOT-7 is a controlled substance in Canada under phenethylamine blanket-ban language.[3]

United Kingdom

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.[4]

See also

References

External links

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