HOT-x
Group of psychedelic drugs
From Wikipedia, the free encyclopedia
HOT-x, also known as 4-alkylthio-2,5-dimethoxy-N-hydroxyphenethylamines or hydroxylated 2C-T derivatives, are a group of psychedelic drugs of the phenethylamine and 2C families.[1][2] They have a hydroxy group (HO) at the amine as well as methoxy groups at the 2 and 5 positions and an alkylthio (T) group at the 4 position of the phenyl ring.[1][2] The HOT-x drugs are the N-hydroxyl analogues of the corresponding 2C-T-x drugs.[1][2]
The HOT-x drugs were synthesized and tested by Alexander Shulgin and were reported by him in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).[1][2]
Use and effects
| Compound | Chemical name | Dose | Duration | |
|---|---|---|---|---|
| HOT-2 (N-hydroxy-2C-T-2) | N-Hydroxy-4-ethylthio-2,5-dimethoxyphenethylamine | 10–18 mg | 6–10 hours | |
| HOT-7 (N-hydroxy-2C-T-7) | N-Hydroxy-4-propylthio-2,5-dimethoxyphenethylamine | 15–25 mg | 6–8 hours | |
| HOT-17 (N-hydroxy-2C-T-17) | N-Hydroxy-4-sec-butylthio-2,5-dimethoxyphenethylamine | 70–120 mg | 12–18 hours | |
| Refs: [2][3][4] | ||||
All three of the HOT-x drugs produce psychedelic effects according to Shulgin.[1][2] The HOT-x drugs are said to be very similar to their 2C-T counterparts in terms of properties and effects and may act as prodrugs to these compounds.[2]
Interactions
Society and culture
Legal status
Canada
The HOT-x drugs are controlled substances in Canada under phenethylamine blanket-ban language.[5]
See also
- 2C (psychedelics)
- Substituted methoxyphenethylamine
- N-Hydroxyamphetamine
- MDOH (MDH; N-OH-MDA)
- MDHMA (FLEA; N-OH-MDMA)
- 2C-B-OH (N-hydroxy-2C-B)
- N-Hydroxy-DOM
- N-Hydroxy-AMT