HOXA7

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.^[5][6][7]

AliasesHOXA7, ANTP, HOX1, HOX1.1, HOX1A, homeobox A7

External IDsOMIM: 142950; MGI: 96179; HomoloGene: 56001; GeneCards: HOXA7; OMA:HOXA7 - orthologs

Chr.Chromosome 7 (human)^[1]

End27,157,936 bp^[1]

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HOXA7
Identifiers
Aliases	HOXA7, ANTP, HOX1, HOX1.1, HOX1A, homeobox A7
External IDs	OMIM: 142950; MGI: 96179; HomoloGene: 56001; GeneCards: HOXA7; OMA:HOXA7 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p15.2 Start 27,153,716 bp[1] End 27,157,936 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 25.4 cM Start 52,191,471 bp[2] End 52,198,834 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte mucosa of transverse colon secondary oocyte sperm biceps brachii tendon of biceps brachii Skeletal muscle tissue of biceps brachii gonad right adrenal gland right adrenal cortex Top expressed in tail of embryo zygote right kidney secondary oocyte thoracic vertebral column proximal tubule muscle of thigh embryo neural tube efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component nucleus nucleoplasm nuclear membrane Biological process embryonic skeletal system morphogenesis negative regulation of monocyte differentiation negative regulation of keratinocyte differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II stem cell differentiation transcription, DNA-templated negative regulation of cell-matrix adhesion multicellular organism development angiogenesis negative regulation of transcription, DNA-templated negative regulation of leukocyte migration anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3204 15404 Ensembl ENSG00000122592 ENSMUSG00000038236 UniProt P31268 P02830 RefSeq (mRNA) NM_006896 NM_010455 RefSeq (protein) NP_008827 NP_034585 Location (UCSC) Chr 7: 27.15 – 27.16 Mb Chr 6: 52.19 – 52.2 Mb PubMed search [3] [4]
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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.^[7]