HOXB3

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.^[5][6][7]

AliasesHOXB3, HOX2, HOX2G, Hox-2.7, homeobox B3

External IDsOMIM: 142966; MGI: 96184; HomoloGene: 1617; GeneCards: HOXB3; OMA:HOXB3 - orthologs

Chr.Chromosome 17 (human)^[1]

End48,604,912 bp^[1]

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HOXB3
Identifiers
Aliases	HOXB3, HOX2, HOX2G, Hox-2.7, homeobox B3
External IDs	OMIM: 142966; MGI: 96184; HomoloGene: 1617; GeneCards: HOXB3; OMA:HOXB3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,548,870 bp[1] End 48,604,912 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.84 cM Start 96,214,152 bp[2] End 96,238,756 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube corpus epididymis caput epididymis seminal vesicula gastric mucosa muscle layer of sigmoid colon tail of epididymis transverse colon beta cell endometrium Top expressed in efferent ductule migratory enteric neural crest cell tail of embryo vas deferens medullary collecting duct inferior ganglion of vagus nerve hair follicle abdominal wall Paneth cell thoracic vertebral column More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process embryonic skeletal system morphogenesis multicellular organism development glossopharyngeal nerve morphogenesis definitive hemopoiesis thyroid gland development cartilage development face development regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of neurogenesis rhombomere development angiogenesis hematopoietic progenitor cell differentiation transcription, DNA-templated anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3213 15410 Ensembl ENSG00000120093 ENSMUSG00000048763 UniProt P14651 P09026 RefSeq (mRNA) NM_002146 NM_001330322 NM_001330323 NM_001384747 NM_001384749 NM_001384750 NM_001079869 NM_010458 RefSeq (protein) NP_001317251 NP_001317252 NP_002137 NP_001073338 NP_034588 Location (UCSC) Chr 17: 48.55 – 48.6 Mb Chr 11: 96.21 – 96.24 Mb PubMed search [3] [4]
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This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).^[7]