HOXB4

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.[5][6][7]

AliasesHOXB4, HOX-2.6, HOX2, HOX2F, homeobox B4
End48,578,350 bp[1]
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HOXB4
Identifiers
AliasesHOXB4, HOX-2.6, HOX2, HOX2F, homeobox B4
External IDsOMIM: 142965; MGI: 96185; HomoloGene: 32095; GeneCards: HOXB4; OMA:HOXB4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024015

NM_010459

RefSeq (protein)

NP_076920

NP_034589

Location (UCSC)Chr 17: 48.58 – 48.58 MbChr 11: 96.21 – 96.21 Mb
PubMed search[3][4]
Wikidata
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Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.[7]

See also

References

Further reading

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