HOXB7

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[5][6]

AliasesHOXB7, HHO.C1, HOX2, HOX2C, Hox-2.3, homeobox B7
End48,633,572 bp[1]
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HOXB7
Identifiers
AliasesHOXB7, HHO.C1, HOX2, HOX2C, Hox-2.3, homeobox B7
External IDsOMIM: 142962; MGI: 96188; HomoloGene: 55828; GeneCards: HOXB7; OMA:HOXB7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004502

NM_010460

RefSeq (protein)

NP_004493

NP_034590

Location (UCSC)Chr 17: 48.61 – 48.63 MbChr 11: 96.18 – 96.18 Mb
PubMed search[3][4]
Wikidata
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Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[7]

Interactions

HOXB7 has been shown to interact with PBX1[8] and CREB-binding protein.[9]

See also

References

Further reading

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