HOXB7
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[5][6]
External IDsOMIM: 142962; MGI: 96188; HomoloGene: 55828; GeneCards: HOXB7; OMA:HOXB7 - orthologs
Function
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[7]
Interactions
HOXB7 has been shown to interact with PBX1[8] and CREB-binding protein.[9]