HOXB9

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.[5][6][7]

AliasesHOXB9, HOX-2.5, HOX2, HOX2E, homeobox B9
End48,626,358 bp[1]
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HOXB9
Identifiers
AliasesHOXB9, HOX-2.5, HOX2, HOX2E, homeobox B9
External IDsOMIM: 142964; MGI: 96190; HomoloGene: 7367; GeneCards: HOXB9; OMA:HOXB9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024017

NM_008270

RefSeq (protein)

NP_076922

NP_032296

Location (UCSC)Chr 17: 48.62 – 48.63 MbChr 11: 96.16 – 96.17 Mb
PubMed search[3][4]
Wikidata
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Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.[7]

Interactions

HOXB9 has been shown to interact with BTG2[8] and BTG1.[8]

See also

References

Further reading

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