Hippocalcin-like protein 1

Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.^[5][6][7]

AliasesHPCAL1, BDR1, HLP2, VILIP-3, hippocalcin like 1

External IDsOMIM: 600207; MGI: 1855689; HomoloGene: 37586; GeneCards: HPCAL1; OMA:HPCAL1 - orthologs

Chr.Chromosome 2 (human)^[1]

End10,427,617 bp^[1]

Quick facts HPCAL1, Identifiers ...

HPCAL1
Identifiers
Aliases	HPCAL1, BDR1, HLP2, VILIP-3, hippocalcin like 1
External IDs	OMIM: 600207; MGI: 1855689; HomoloGene: 37586; GeneCards: HPCAL1; OMA:HPCAL1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.1 Start 10,302,889 bp[1] End 10,427,617 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.2 Start 17,690,856 bp[2] End 17,791,933 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis paraflocculus of cerebellum right hemisphere of cerebellum frontal pole Brodmann area 10 lateral nuclear group of thalamus cingulate gyrus anterior cingulate cortex right frontal lobe right lung Top expressed in lobe of cerebellum cerebellar vermis entorhinal cortex anterior amygdaloid area dorsomedial hypothalamic nucleus perirhinal cortex paraventricular nucleus of hypothalamus ventral tegmental area granulocyte habenula More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 3241 53602 Ensembl ENSG00000115756 ENSMUSG00000071379 UniProt P37235 P62748 RefSeq (mRNA) NM_001258357 NM_001258358 NM_001258359 NM_002149 NM_134421 NM_016677 NM_001361645 RefSeq (protein) NP_001245286 NP_001245287 NP_001245288 NP_002140 NP_602293 NP_057886 NP_001348574 Location (UCSC) Chr 2: 10.3 – 10.43 Mb Chr 12: 17.69 – 17.79 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the neuron-specific calcium-binding proteins family found in the retina and brain.^[8] It is highly similar to human hippocalcin protein, and nearly identical to rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation, and may be of relevance to neuronal signaling in the central nervous system. There are two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites.^[7]