CDC73

CDC73
Identifiers
Aliases	CDC73, C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX, cell division cycle 73
External IDs	OMIM: 607393; MGI: 2384876; HomoloGene: 11571; GeneCards: CDC73; OMA:CDC73 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	193,254,815 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	143,578,631 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; epithelium of colon; ; monocyte; ; ventricular zone; ; islet of Langerhans; ; stromal cell of endometrium; ; gonad; ; tail of epididymis; ; right ventricle;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; seminal vesicula; ; cumulus cell; ; primitive streak; ; epiblast; ; medial ganglionic eminence; ; yolk sac; ; Gonadal ridge;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II complex binding; protein binding;
Cellular component	nucleoplasm; Cdc73/Paf1 complex; nucleus; cytosol;
Biological process	histone monoubiquitination; regulation of transcription, DNA-templated; positive regulation of mRNA 3'-end processing; histone modification; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; transcription, DNA-templated; stem cell population maintenance; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of Wnt signaling pathway; mRNA polyadenylation; endodermal cell fate commitment; protein destabilization; negative regulation of epithelial cell proliferation; cell cycle; histone H2B ubiquitination; cellular response to lipopolysaccharide; negative regulation of myeloid cell differentiation; negative regulation of fibroblast proliferation; positive regulation of transcription elongation from RNA polymerase II promoter; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; beta-catenin-TCF complex assembly; regulation of cell growth; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; protein ubiquitination; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; negative regulation of apoptotic process; positive regulation of cell cycle G1/S phase transition;
	Sources:Amigo / QuickGO
Orthologs
	79577
	214498
	ENSG00000134371
	ENSMUSG00000026361
	Q6P1J9
	Q8JZM7
	NM_024529
	NM_145991
	NP_078805
	NP_666103
	Wikidata
View/Edit Human	View/Edit Mouse

Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae), also known as CDC73 and parafibromin, is a protein which in humans is encoded by the CDC73 gene.^[5]^[6]^[7]