HS3ST3A1

HS3ST3A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T8T, 1T8U
Identifiers
Aliases	HS3ST3A1, 30ST3A1, 3OST3A1, 3-OST-3A, heparan sulfate-glucosamine 3-sulfotransferase 3A1
External IDs	OMIM: 604057; MGI: 1333861; HomoloGene: 88735; GeneCards: HS3ST3A1; OMA:HS3ST3A1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	13,601,929 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	64,413,667 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; testicle; ; tibia; ; gingival epithelium; ; oral cavity; ; glomerulus; ; metanephric glomerulus; ; seminal vesicula; ; stromal cell of endometrium; ; germinal epithelium;
	Top expressed in
	metatarsal bones; ; condyle; ; second metatarsal bone; ; fifth metatarsal bone; ; iris; ; footplate; ; Gonadal ridge; ; third metatarsal bone; ; ciliary body; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; [heparan sulfate-glucosamine 3-sulfotransferase 3 activity]; [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]; heparan sulfate sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9955
	15478
	ENSG00000153976
	ENSMUSG00000047759
	Q9Y663
	Q8BKN6
	NM_006042
	NM_178870
	NP_006033
	NP_849201
	Wikidata
View/Edit Human	View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.^[5]^[6]

PDBOrtholog search: PDBe RCSB

AliasesHS3ST3A1, 30ST3A1, 3OST3A1, 3-OST-3A, heparan sulfate-glucosamine 3-sulfotransferase 3A1

External IDsOMIM: 604057; MGI: 1333861; HomoloGene: 88735; GeneCards: HS3ST3A1; OMA:HS3ST3A1 - orthologs

Chr.Chromosome 17 (human)^[1]

Quick facts Available structures, PDB ...

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Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family.

It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in the liver and placenta.^[6]

[5]

[6]

[1]

[2]

[3]

[4]

HS3ST3A1

References

Further reading

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