HS3ST3B1

HS3ST3B1
Identifiers
Aliases	HS3ST3B1, 30ST3B1, 3OST3B1, 3-OST-3B, h3-OST-3B, heparan sulfate-glucosamine 3-sulfotransferase 3B1
External IDs	OMIM: 604058; MGI: 1333853; HomoloGene: 88576; GeneCards: HS3ST3B1; OMA:HS3ST3B1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	14,349,404 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	63,813,116 bp
RNA expression pattern
	Top expressed in
	tibia; ; parotid gland; ; epithelium of nasopharynx; ; right lobe of liver; ; palpebral conjunctiva; ; placenta; ; cartilage tissue; ; gingival epithelium; ; germinal epithelium; ; stromal cell of endometrium;
	Top expressed in
	epithelium of stomach; ; left lobe of liver; ; renal corpuscle; ; female external genitalia; ; paramesonephric duct; ; retinal pigment epithelium; ; ciliary body; ; neural layer of retina; ; cornea; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; [heparan sulfate-glucosamine 3-sulfotransferase 3 activity]; [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]; heparan sulfate sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; integral component of plasma membrane; membrane;
Biological process	heparan sulfate proteoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, enzymatic modification; glycosaminoglycan biosynthetic process; protein sulfation;
	Sources:Amigo / QuickGO
Orthologs
	9953
	54710
	ENSG00000125430
	ENSMUSG00000070407
	Q9Y662
	Q9QZS6
	NM_006041
	NM_018805
	NP_006032
	NP_061275
	Wikidata
View/Edit Human	View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene.^[5]^[6] Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.^[6]