HS665

HS665
Clinical data
Other names	HS-665
Drug class	κ-Opioid receptor agonist; Analgesic
Identifiers
	IUPAC name 3-[2-[cyclobutylmethyl(2-phenylethyl)amino]ethyl]phenol;
CAS Number	1409931-92-5;
PubChem CID	71452041;
ChemSpider	28666556;
ChEMBL	ChEMBL2180639;
CompTox Dashboard (EPA)	DTXSID401336626 ;
Chemical and physical data
Formula	C21H27NO
Molar mass	309.453 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC(C1)CN(CCC2=CC=CC=C2)CCC3=CC(=CC=C3)O;
	InChI InChI=1S/C21H27NO/c23-21-11-5-8-19(16-21)13-15-22(17-20-9-4-10-20)14-12-18-6-2-1-3-7-18/h1-3,5-8,11,16,20,23H,4,9-10,12-15,17H2; Key:YNVKFHIWFDRVNY-UHFFFAOYSA-N;

HS665 is a drug which acts as a potent and selective κ-opioid receptor agonist, and has analgesic effects in animal studies.^[1]^[2]^[3]^[4] HS665 is not an agonist for the μ-opioid receptor, leading to less potential for misuse.^[5]