HSD17B7

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.^[5][6][7][8]

AliasesHSD17B7, PRAP, SDR37C1, hydroxysteroid (17-beta) dehydrogenase 7, hydroxysteroid 17-beta dehydrogenase 7

External IDsOMIM: 606756; MGI: 1330808; HomoloGene: 40728; GeneCards: HSD17B7; OMA:HSD17B7 - orthologs

EC number1.1.1.62

Chr.Chromosome 1 (human)^[1]

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HSD17B7
Identifiers
Aliases	HSD17B7, PRAP, SDR37C1, hydroxysteroid (17-beta) dehydrogenase 7, hydroxysteroid 17-beta dehydrogenase 7
External IDs	OMIM: 606756; MGI: 1330808; HomoloGene: 40728; GeneCards: HSD17B7; OMA:HSD17B7 - orthologs
EC number	1.1.1.62
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 162,790,702 bp[1] End 162,812,823 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 169,777,104 bp[2] End 169,796,810 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex anterior pituitary C1 segment upper lobe of left lung islet of Langerhans ectocervix Top expressed in vestibular sensory epithelium skin of external ear Paneth cell ciliary body facial motor nucleus condyle hair follicle substantia nigra iris medullary collecting duct More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity estradiol 17-beta-dehydrogenase activity 3-keto sterol reductase activity Cellular component integral component of membrane plasma membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process estrogen biosynthetic process cholesterol biosynthetic process lipid metabolism steroid biosynthetic process nervous system development cell differentiation embryonic skeletal system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51478 15490 Ensembl ENSG00000132196 ENSMUSG00000026675 UniProt P56937 O88736 RefSeq (mRNA) NM_001304512 NM_001304513 NM_016371 NM_010476 RefSeq (protein) NP_001291441 NP_001291442 NP_057455 NP_034606 Location (UCSC) Chr 1: 162.79 – 162.81 Mb Chr 1: 169.78 – 169.8 Mb PubMed search [3] [4]
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The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM]^[8]