HTR3A

5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesHTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A

External IDsOMIM: 182139; MGI: 96282; HomoloGene: 671; GeneCards: HTR3A; OMA:HTR3A - orthologs

Chr.Chromosome 11 (human)^[1]

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HTR3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PIR
Identifiers
Aliases	HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A
External IDs	OMIM: 182139; MGI: 96282; HomoloGene: 671; GeneCards: HTR3A; OMA:HTR3A - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.2 Start 113,975,075 bp[1] End 113,990,313 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 48,810,513 bp[2] End 48,822,399 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spinal ganglia testicle trigeminal ganglion lymph node islet of Langerhans appendix gingival epithelium muscle layer of sigmoid colon caudate nucleus minor salivary glands Top expressed in lumbar spinal ganglion Rostral migratory stream facial motor nucleus medial ganglionic eminence right ventricle embryo carotid body embryo dentate gyrus of hippocampal formation granule cell retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ligand-gated ion channel activity serotonin binding extracellular ligand-gated ion channel activity serotonin-gated cation-selective channel activity ion channel activity transmembrane signaling receptor activity Cellular component cytoplasm integral component of membrane postsynaptic membrane membrane plasma membrane synapse axon cell junction soma serotonin-activated cation-selective channel complex cleavage furrow glutamatergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane integral component of plasma membrane neuron projection Biological process response to cocaine cellular response to growth factor stimulus ion transport response to ethanol positive regulation of ion transmembrane transporter activity signal transduction ion transmembrane transport serotonin receptor signaling pathway chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3359 15561 Ensembl ENSG00000166736 ENSMUSG00000032269 UniProt P46098 P23979 RefSeq (mRNA) NM_000869 NM_001161772 NM_213621 NM_001099644 NM_013561 RefSeq (protein) NP_000860 NP_001155244 NP_998786 NP_001093114 NP_038589 Location (UCSC) Chr 11: 113.98 – 113.99 Mb Chr 9: 48.81 – 48.82 Mb PubMed search [3] [4]
Wikidata
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The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]