HW201877

HW201877 is a drug which acts as a potent inhibitor of the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH). It increases levels of prostaglandin E2 and stimulates tissue regeneration, and has been researched in animal studies for treatment of conditions such as inflammatory bowel disease and idiopathic pulmonary fibrosis.^[1]

Drug class15-PGDH inhibitor

CAS Number

• 2927452-83-1

PubChem CID

• 169836897

ChemSpider

• 133325048

Quick facts Clinical data, Drug class ...

HW201877

Clinical data
Drug class	15-PGDH inhibitor
Identifiers
IUPAC name 7-[(1aS,7bR)-6-(4,4-difluoropiperidine-1-carbonyl)-1,1a,2,7b-tetrahydro-3H-cyclopropa[c][1,8]naphthyridin-3-yl]-2-methyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
CAS Number	2927452-83-1
PubChem CID	169836897
ChemSpider	133325048
Chemical and physical data
Formula	C22H22F2N6O2
Molar mass	440.455 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C1N2C=CC(=CC2=NN1C)N1C[C@H]2C[C@H]2c2cc(cnc12)C(=O)N1CCC(F)(F)CC1
InChI InChI=1S/C22H22F2N6O2/c1-27-21(32)29-5-2-15(10-18(29)26-27)30-12-14-9-16(14)17-8-13(11-25-19(17)30)20(31)28-6-3-22(23,24)4-7-28/h2,5,8,10-11,14,16H,3-4,6-7,9,12H2,1H3/t14-,16-/m1/s1 Key:KDAKIHHOWNCOTC-GDBMZVCRSA-N

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