HYAL3

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.^[5][6]

AliasesHYAL3, HYAL-3, LUCA-3, LUCA3, hyaluronoglucosaminidase 3, hyaluronidase 3

External IDsOMIM: 604038; MGI: 1330288; HomoloGene: 2626; GeneCards: HYAL3; OMA:HYAL3 - orthologs

Chr.Chromosome 3 (human)^[1]

End50,299,405 bp^[1]

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HYAL3
Identifiers
Aliases	HYAL3, HYAL-3, LUCA-3, LUCA3, hyaluronoglucosaminidase 3, hyaluronidase 3
External IDs	OMIM: 604038; MGI: 1330288; HomoloGene: 2626; GeneCards: HYAL3; OMA:HYAL3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,292,831 bp[1] End 50,299,405 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 58.19 cM Start 107,458,017 bp[2] End 107,464,558 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad bone marrow prefrontal cortex left testis right hemisphere of cerebellum right testis superior frontal gyrus primary visual cortex right frontal lobe Top expressed in embryo embryo right kidney blastocyst proximal tubule spermatid zygote vestibular membrane of cochlear duct ventricular zone tail of embryo More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity, acting on glycosyl bonds protein binding hyaluronoglucuronidase activity hydrolase activity catalytic activity hyalurononglucosaminidase activity Cellular component extracellular region acrosomal vesicle acrosomal membrane lysosome endosome early endosome endoplasmic reticulum plasma membrane membrane cytoplasmic vesicle sperm midpiece Biological process cellular response to UV-B cartilage development response to antibiotic cellular response to tumor necrosis factor metabolism cellular response to interleukin-1 inflammatory response hyaluronan catabolic process carbohydrate metabolic process response to virus ovarian follicle atresia single fertilization penetration of zona pellucida negative regulation of ovarian follicle development positive regulation of acrosomal vesicle exocytosis viral entry into host cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8372 109685 Ensembl ENSG00000186792 ENSMUSG00000036091 UniProt O43820 Q8VEI3 RefSeq (mRNA) NM_003549 NM_001200029 NM_001200030 NM_001200031 NM_001200032 NM_178020 RefSeq (protein) NP_001186958 NP_001186959 NP_001186960 NP_001186961 NP_003540 NP_821139 Location (UCSC) Chr 3: 50.29 – 50.3 Mb Chr 9: 107.46 – 107.46 Mb PubMed search [3] [4]
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This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.^[6]