Helper-component proteinase
From Wikipedia, the free encyclopedia
Helper-component proteinase (EC 3.4.22.45, HC-Pro) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Hydrolyses a Gly-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-Gly, in the processing of the potyviral polyprotein
| Helper-component proteinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.22.45 | ||||||||
| CAS no. | 124566-20-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is present in plant RNA viruses of the Potyviridae family. HC-Pro is encoded by all potyviruses, but is absent in some members of the Ipomovirus genus.[3] HC-Pro is involved in virus transmission, virus polyprotein processing, and suppression of RNA silencing, an antiviral mechanism of plants.[4]
