Hippocalcin
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Hippocalcin is a protein that in humans is encoded by the HPCA gene.[5][6]
External IDsOMIM: 142622; MGI: 1336200; HomoloGene: 55634; GeneCards: HPCA; OMA:HPCA - orthologs
Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins.[7][8] It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.[9]
Processes
Hippocalcin takes part in the following processes:
- Activation of PLD1 and PLD2 expression
- Inhibition of apoptosis
- MAP kinase signalling
- Involved in long term depression in hippocampal neuron
- Required for normal spatial learning
Interactions
Hippocalcin interacts with following proteins:
- Neuronal apoptosis inhibitory protein (NAIP)
- Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
- The b2 adaptin of the AP2 complex
- Calcium-dependent activator protein for secretion (CADPS)