Hydrocotarnine

Hydrocotarnine
Clinical data
Trade names	Pavinal
Other names	Hydrocotarnin; 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline
Drug class	Narcotic Analgesics based on DEA classification
Legal status
Legal status	US: Schedule II; Pavinal is a prescription-only drug;; Hydrocotarnine in general is not controlled.
Identifiers
	IUPAC name 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline;
CAS Number	550-10-7;
PubChem CID	3646;
ChemSpider	3520;
UNII	G22L6JNE61;
KEGG	D02031;
ChEBI	CHEBI:92664;
ChEMBL	ChEMBL1606295;
CompTox Dashboard (EPA)	60203535;
Chemical and physical data
Formula	C12H15NO3
Molar mass	221.256 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCC2=CC3=C(C(=C2C1)OC)OCO3;
	InChI InChI=1S/C12H15NO3/c1-13-4-3-8-5-10-12(16-7-15-10)11(14-2)9(8)6-13/h5H,3-4,6-7H2,1-2H3; Key:XXANNZJIZQTCBP-UHFFFAOYSA-N;

Hydrocotarnine, used in combination with oxycodone under the trade name Pavinal (Japan), is a substituted tetrahydroisoquinoline alkaloid, non-narcotic analgesic. It is also classified as a cyclized phenylethylamine. Hydrocotarnine is a drug that is primarily used in combination with oxycodone to enhance its analgesic effect. The mechanism of action of hydrocotarnine is not fully understood, but it is known that it is one of the non-narcotic alkaloids of the poppy Papaver somniferum. Combinations of oxycodone and hydrocotarnine are taken orally and by injection.^[2]^[3]^[4]^[5]^[6]^[7]^[8] Hydrocotarnine is reported as a natural product present in Corydalis ophiocarpa, Corydalis ochotensis, and Corydalis heterocarpa var. japonica.^[9]