ID2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.[5]

PDBOrtholog search: PDBe RCSB
AliasesID2, GIG8, ID2A, ID2H, bHLHb26, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2
Quick facts Available structures, PDB ...
ID2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesID2, GIG8, ID2A, ID2H, bHLHb26, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2
External IDsOMIM: 600386; MGI: 96397; HomoloGene: 1632; GeneCards: ID2; OMA:ID2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002166

NM_010496

RefSeq (protein)

NP_002157

NP_034626

Location (UCSC)Chr 2: 8.68 – 8.68 MbChr 12: 25.14 – 25.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene.[6] The ID2 protein may play a role in the development and resistance to therapies of glioblastoma, the most aggressive of brain cancers.[7]

Interactions

ID2 has been shown to interact with MyoD[8] and NEDD9.[9]

See also

References

Further reading

Related Articles

Wikiwand AI